Mass spectrometry in drug metabolism and pharmacokinetics

Mass spectrometry in drug metabolism and pharmacokinetics /

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This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods...

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Bibliographic Details
Other Authors: Ramanathan, Ragu
Format: Electronic eBook
Language:English
Published: Hoboken, N.J. : Wiley, ?2009.
Subjects:
Drugs > Metabolism > Research > Methodology.
Drugs > Design.
Mass spectrometry.
Pharmacokinetcs > Research > Methodology.
Pharmacokinetics.
Pharmaceutical Preparations > metabolism
Drug Design
Drug Evaluation, Preclinical > methods
Mass Spectrometry > methods
Pharmacokinetics
Mass Spectrometry
Online Access:Full text (Wentworth users only)
Table of Contents:
  • Evolving role of mass spectrometry in drug discovery and development / Dil M. Ramanathan and Richard M. LeLacheur
  • Quantitative bioanalysis in drug discovery and development : principles and applications / Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen
  • Quadrupole, triple-quadrupole, and hybrid linear ion trap mass spectrometers in metabolite analysis / Elliott B. Jones
  • Applications of quadrupole time-of-flight mass spectrometry in reactive metabolite screening / Jose M. Castro-Perez
  • Changing role of FTMS in drug metabolism / Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders
  • High-resolution LC-MS based mass defect filter approach : basic concept and application in metabolite detection / Haiying Zhang [and others].
  • Applications of high-sensitivity mass spectrometry and radioactivity detection techniques in drug metabolism studies / Wing W. Lam [and others]
  • Online electrochemical-LC-MS techniques for profiling and characterizing metabolites and degradants / Paul H. Gamache [and others]
  • LC-MS methods with hydrogen/deuterium exchange for identification of hydroxylamine, n-oxide, and hydroxylated analogs of desloratadine / Natalia A. Penner [and others]
  • Turbulent-flow LC-MS : applications for accelerating pharmacokinetic profiling and metabolite identification / Joseph L. Herman and Joseph M. Di Bussolo
  • Desorption ionization techniques for quantitative analysis of drug molecules / Jason S. Gobey, John Janiszewski, and Mark J. Cole
  • MALDI imaging mass spectrometry for direct tissue analysis of pharmaceuticals / Yunsheng Hsieh and Walter A. Korfmacher.

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